gastroplus tm  (Simcyp)

Journal: Pharmaceutics

Article Title: Physiologically Based Pharmacokinetic Modeling in Neonates: Current Status and Future Perspectives

doi: 10.3390/pharmaceutics15122765

Figure Lengend Snippet: Neonatal PBPK modeling studies.

Article Snippet: Currently, mainstream modeling tools include Gastroplus TM , Simcyp ® , PK-Sim ® , and MATLAB Simbiology.

Techniques: Injection, Concentration Assay, Clinical Proteomics, Dissolution, Quantitative Proteomics, Activity Assay, Expressing, In Vitro, In Vivo, Modification, Inhibition, Recombinant, Software

Journal: Pharmaceutics

Article Title: The Role of Paracellular Transport in the Intestinal Absorption and Biopharmaceutical Characterization of Minoxidil

doi: 10.3390/pharmaceutics14071360

Figure Lengend Snippet: The selected input parameters for minoxidil absorption simulation.

Article Snippet: In-silico simulations were performed with the GastroPlus TM software package (v. 9.7.0009, Simulations Plus Inc., Lancaster, CA, USA).

Techniques: Molecular Weight, Solubility, Permeability, Diffusion-based Assay, Concentration Assay, Clinical Proteomics

Journal: Pharmaceutics

Article Title: Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin

doi: 10.3390/pharmaceutics13111873

Figure Lengend Snippet: Plasma concentration–time profile observed by Pentikäinen et al. (squares) and the predicted plasma concentration–time profile by GastroPlus TM (solid line) in a healthy subject.

Article Snippet: GastroPlus TM software (version 9.5 Simulations Plus, Inc., Lancaster, CA, USA) was used for gastrointestinal simulations of metformin absorption in healthy subjects, as well as subjects with obesity.

Techniques: Clinical Proteomics, Concentration Assay

Journal: Pharmaceutics

Article Title: Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin

doi: 10.3390/pharmaceutics13111873

Figure Lengend Snippet: Regional gastrointestinal absorption predicted by GastroPlus TM in healthy human subjects following oral administration of 500 mg of metformin.

Article Snippet: GastroPlus TM software (version 9.5 Simulations Plus, Inc., Lancaster, CA, USA) was used for gastrointestinal simulations of metformin absorption in healthy subjects, as well as subjects with obesity.

Techniques:

Journal: Pharmaceutics

Article Title: Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin

doi: 10.3390/pharmaceutics13111873

Figure Lengend Snippet: Plasma concentration–time profile observed by Padwal et al. (squares) and the predicted plasma concentration–time profile by GastroPlus TM (solid line) in the control subject (with obesity).

Article Snippet: GastroPlus TM software (version 9.5 Simulations Plus, Inc., Lancaster, CA, USA) was used for gastrointestinal simulations of metformin absorption in healthy subjects, as well as subjects with obesity.

Techniques: Clinical Proteomics, Concentration Assay, Control

Journal: Pharmaceutics

Article Title: Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin

doi: 10.3390/pharmaceutics13111873

Figure Lengend Snippet: Plasma concentration–time profile observed by Padwal et al. (squares) and the predicted plasma concentration–time profile by GastroPlus TM (solid line) in the post-RYGB subject.

Article Snippet: GastroPlus TM software (version 9.5 Simulations Plus, Inc., Lancaster, CA, USA) was used for gastrointestinal simulations of metformin absorption in healthy subjects, as well as subjects with obesity.

Techniques: Clinical Proteomics, Concentration Assay

Journal: Pharmaceutics

Article Title: Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin

doi: 10.3390/pharmaceutics13111873

Figure Lengend Snippet: Plasma concentration–time profile observed by Padwal et al. (squares) and the predicted plasma concentration–time profile by GastroPlus TM (solid line) in the post-RYGB subject with adjusted physiology.

Article Snippet: GastroPlus TM software (version 9.5 Simulations Plus, Inc., Lancaster, CA, USA) was used for gastrointestinal simulations of metformin absorption in healthy subjects, as well as subjects with obesity.

Techniques: Clinical Proteomics, Concentration Assay